the main aim of our reviews within the final decade used to be a scientific research of maternal ailments while pregnant to bare their attainable antagonistic results on start results. the 2 most crucial components of baby mortality have been parti- larly analyzed: structural start defects, often called congenital abnormalities (CAs) and preterm beginning (PB). generally the ambitions of scienti c reports may be both to check a brand new speculation or to con rm or confront formerly released effects. even if, much less often the authors/scientists have own motivations made up our minds via their expert actions. The authors of this booklet are practising physicians and genetic epidemiologist who're mostly drawn to the subsequent 3 sensible questions: 1. the potential adversarial results of pharmaceutical items. the prospective t- atogenic power of approximately a hundred and seventy medicinal drugs has been evaluated very completely utilizing the information set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) within the final 50 years. those medicinal drugs have been used to regard maternal illnesses and the ndings of our population-based case-control experiences can be mentioned during this booklet and are proven within the Appendix on the finish of the booklet. although, our lengthy stories confirmed difficulties within the drug teratology. ordinarily the evaluate of scientific doses of those medicines is a very dif- cult problem as a result of the modi cation results of confounders. This challenge influenced one of many authors to set up a brand new version of catastrophe epidemiology.